dor_id: 4133800

506.#.#.a: Público

590.#.#.d: Los artículos enviados a "TIP Revista especializada en Ciencias químico-biológicas", se juzgan por medio de un proceso de revisión por pares

510.0.#.a: Consejo Nacional de Ciencia y Tecnología (CONACyT); Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal (Latindex) Scientific Electronic Library Online (SciELO); Red de Revistas Científicas de América Latina y el Caribe, España y Portugal (Redalyc); Directory of Open Access Journals (DOAJ); Web Of Science (WoS); EBSCO, Medigraphic, Indice de Revistas Latinoamericanas en Ciencias (Periódica)

561.#.#.u: https://www.zaragoza.unam.mx/

650.#.4.x: Biología y Química

336.#.#.b: article

336.#.#.3: Artículo de Investigación

336.#.#.a: Artículo

351.#.#.6: http://tip.zaragoza.unam.mx/index.php/tip/index

351.#.#.b: TIP Revista especializada en Ciencias Químico-Biológicas

351.#.#.a: Artículos

harvesting_group: RevistasUNAM

270.1.#.p: Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

590.#.#.c: Open Journal Systems (OJS)

270.#.#.d: MX

270.1.#.d: México

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883.#.#.u: https://revistas.unam.mx/catalogo/

883.#.#.a: Revistas UNAM

590.#.#.a: Coordinación de Difusión Cultural

883.#.#.1: https://www.publicaciones.unam.mx/

883.#.#.q: Dirección General de Publicaciones y Fomento Editorial, UNAM

850.#.#.a: Universidad Nacional Autónoma de México

856.4.0.u: http://tip.zaragoza.unam.mx/index.php/tip/article/view/465/399

100.1.#.a: Martínez-Cortés, Dulce Maribel; Vera-Pérez, Jonathan; Gómez-y-Gómez, Yolanda

524.#.#.a: Martínez-Cortés, Dulce Maribel, et al. (2022). Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia. TIP Revista Especializada en Ciencias Químico-Biológicas; Vol. 25, 2022. Recuperado de https://repositorio.unam.mx/contenidos/4133800

245.1.0.a: Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia

502.#.#.c: Universidad Nacional Autónoma de México

561.1.#.a: Facultad de Estudios Superiores Zaragoza, UNAM

264.#.0.c: 2022

264.#.1.c: 2022-08-08

653.#.#.a: ultrathin films; Agastache mexicana; oral administration; insomnia; películas ultradelgadas; Agastache mexicana; administración oral; insomnio

506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY-NC-ND 4.0 Internacional, https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico revistatip@yahoo.com

884.#.#.k: http://tip.zaragoza.unam.mx/index.php/tip/article/view/465

001.#.#.#: tip.oai:ojs.ojs.escire.net:article/465

041.#.7.h: spa

520.3.#.a: Ultrathin oral films are novel delivery systems that do not require water to swallow, show rapid systemic release, and allow a comfortable and precise dosage. These films represent an option for administering active metabolites from medicinal plants used against insomnia, such as Agastache mexicana. However, incorporating complex bioactive molecules can compromise the functionality of the films. This study evaluated the physicochemical properties and biological activity of sodium alginate films added with the ethanolic extracts of Agastache Mexicana. After incorporating the extracts, the films preserved their homogeneous morphology, thickness (<50 µm), and solubility time (<10 min). In contrast, hardness increased more than 40%, and elasticity increased 60%. Infrared spectroscopy analysis revealed that, after the preparation of the films, the functional groups of the extracts and the chemical structure of the ultrathin films were maintained. Moreover, we demonstrated that the hypnotic effect of Agastache mexicana was preserved, since the sleep onset latency and total sleep time in a murine model were similar between the liquid extract and the film formulation. These data support the use of ultrathin films with natural extracts as a potential treatment for sleep disorders like insomnia.

773.1.#.t: TIP Revista Especializada en Ciencias Químico-Biológicas; Vol. 25 (2022)

773.1.#.o: http://tip.zaragoza.unam.mx/index.php/tip/index

022.#.#.a: ISSN electrónico: 2395-8723; ISSN impreso: 1405-888X

310.#.#.a: Publicación contínua

264.#.1.b: Facultad de Estudios Superiores Zaragoza, UNAM

doi: https://doi.org/10.22201/fesz.23958723e.2022.465

handle: 373f72c59524d0ba

harvesting_date: 2023-02-15 12:00:00.0

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file_creation_date: 2022-08-08 04:31:06.0

file_modification_date: 2022-08-08 04:31:14.0

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245.1.0.b: Películas orales ultradelgadas con extractos de Agastache mexicana con actividad hipnótica como potencial tratamiento del insomnio

last_modified: 2023-02-15 12:00:00

license_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.es

license_type: by-nc-nd

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Artículo

Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia

Martínez-Cortés, Dulce Maribel; Vera-Pérez, Jonathan; Gómez-y-Gómez, Yolanda

Facultad de Estudios Superiores Zaragoza, UNAM, publicado en TIP Revista especializada en Ciencias Químico-Biológicas, y cosechado de Revistas UNAM

Licencia de uso

Procedencia del contenido

Cita

Martínez-Cortés, Dulce Maribel, et al. (2022). Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia. TIP Revista Especializada en Ciencias Químico-Biológicas; Vol. 25, 2022. Recuperado de https://repositorio.unam.mx/contenidos/4133800

Descripción del recurso

Autor(es)
Martínez-Cortés, Dulce Maribel; Vera-Pérez, Jonathan; Gómez-y-Gómez, Yolanda
Tipo
Artículo de Investigación
Área del conocimiento
Biología y Química
Título
Ultrathin oral films with extracts of Agastache mexicana and its hypnotic activity as a potential treatment for insomnia
Fecha
2022-08-08
Resumen
Ultrathin oral films are novel delivery systems that do not require water to swallow, show rapid systemic release, and allow a comfortable and precise dosage. These films represent an option for administering active metabolites from medicinal plants used against insomnia, such as Agastache mexicana. However, incorporating complex bioactive molecules can compromise the functionality of the films. This study evaluated the physicochemical properties and biological activity of sodium alginate films added with the ethanolic extracts of Agastache Mexicana. After incorporating the extracts, the films preserved their homogeneous morphology, thickness (<50 µm), and solubility time (<10 min). In contrast, hardness increased more than 40%, and elasticity increased 60%. Infrared spectroscopy analysis revealed that, after the preparation of the films, the functional groups of the extracts and the chemical structure of the ultrathin films were maintained. Moreover, we demonstrated that the hypnotic effect of Agastache mexicana was preserved, since the sleep onset latency and total sleep time in a murine model were similar between the liquid extract and the film formulation. These data support the use of ultrathin films with natural extracts as a potential treatment for sleep disorders like insomnia.
Tema
ultrathin films; Agastache mexicana; oral administration; insomnia; películas ultradelgadas; Agastache mexicana; administración oral; insomnio
Idioma
spa
ISSN
ISSN electrónico: 2395-8723; ISSN impreso: 1405-888X

Enlaces