Artículo

The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine

Facultad de Medicina Veterinaria y Zootecnia, UNAM, publicado en Veterinaria México OA, y cosechado de Revistas UNAM

Licencia de uso

Procedencia del contenido

Entidad o dependencia
Facultad de Medicina Veterinaria y Zootecnia, UNAM
Revista
Repositorio
Contacto
Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

Cita

The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine. (2017). Veterinaria México OA; Vol 4, No 3, 2017. Recuperado de https://repositorio.unam.mx/contenidos/60420

Descripción del recurso

Colaborador(es)
Serrato López, Ana G. ; Montesinos Montesinos, Juan J. ; Anzaldúa Arce, Santiago R.
Afiliación del colaborador
Departamento de Morfología. Facultad de Medicina Veterinaria y Zootecnia. Universidad Nacional Autónoma de México. Avenida Universidad #3000, Delegación Coyoacán, D.F CP 04510, Mexico City, Mexico. Laboratorio de Células Troncales Mesenquimales, Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México, México. C.P. 6720; Laboratorio de Células Troncales Mesenquimales, Unidad de Investigación Médica en Enfermedades Oncológicas, Centro Médico Nacional Siglo XXI, IMSS, Ciudad de México, México. C.P. 6720; Departamento de Morfología. Facultad de Medicina Veterinaria y Zootecnia. Universidad Nacional Autónoma de México. Avenida Universidad #3000, Delegación Coyoacán, D.F CP 04510, Mexico City, Mexico.
Tipo
Artículo de Investigación
Área del conocimiento
Biotecnología y Ciencias Agropecuarias
Título
The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine
Fecha
2017-06-30
Resumen
Veterinaria México OA ISSN: 2448-6760 Cite this as: • Serrato López AG, Montesinos Montesinos JJ, Anzaldúa Arce SR. The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine. Veterinaria México OA. 2017;4(3). doi: 10.21753/vmoa.4.3.441. Mesenchymal stem cells (MSCs) have been isolated from the endometrium of humans, mice, cows, pigs and ewes. Typically, these cells are detected in the deep regions of the endometrium, closer to the union with the myometrium. MSCs possess characteristics such as clonogenicity and multipotentiality since they can differentiate in vitro into adipogenic, chondrogenic and osteogenic lineages. These cells can be induced to differentiate in vitro not only into the mesodermal lineage but also into the endodermal and ectodermal lineages. Therefore, MSCs show a great regenerative capacity for various organs and tissues, including the endometrium. Some advantages of endometrial MSCs compared with other MSC sources are their immune modulating activity, their ease of obtainment, and the amount of sample that may be collected. The study of endometrial MSCs in domestic animals is a new and promising field because increasing our understanding of the physiology and biology of these cells may lead to a better understanding of the physiopathology of reproductive diseases, and the development of treatment methods for infertility problems. In other veterinary medicine fields, MSCs can be used for the treatment of autoimmune diseases, cardiac affections, musculoskeletal and articular lesions, muscle degeneration, type 1 diabetes, urinary tract diseases, neurodegenerative processes and tumours. Finally, MSCs are also an important clinical tool for tissue engineering and regenerative medicine. The aim of this review is to present an updated outlook of the knowledge regarding endometrial MSCs and their possible applications in veterinary medicine. Figure 1: Immunoregulatory ability of MSCs. MSCs regulate the functions of NK cells, dendritic cells (DC) and T lymphocytes. The immunosuppressive effect may occur through the secretion of different factors or through cellular contact (black arrows). The former pathway involves TGFß, HGF, IL-10, PGE2, and HLA-G5, whereas the latter pathway involves the products of IDO enzyme activity, PD-L1, HLA-G1, ICAM-I and VCAM-I. Pro-inflammatory cytokines (IFN-?) secreted by NK cells and activated T lymphocytes favour the immunoregulatory activity of MSCs (dotted lines), because they increase or induce the secretion of molecules that regulate the functions of the distinct cellular components of the immune system. Modified from Montesinos et al, and Ma et al.19,66
Tema
Uterus; mesenchymal stem cells; regenerative medicine; immune modulation; veterinary medicine
Idioma
eng
ISSN
2448-6760

Enlaces