dor_id: 60420

506.#.#.a: Público

590.#.#.d: Los artículos enviados a la revista "Veterinaria México OA", se juzgan por medio de un proceso de revisión por pares

510.0.#.a: Consejo Nacional de Ciencia y Tecnología (CONACyT); Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal (Latindex); Scientific Electronic Library Online (SciELO); Bibliografía Latinoamericana (Biblat); La Red de Revistas Científicas de América Latina y el Caribe, España y Portugal (Redalyc); Connecting research and researchers (ORCiD)

561.#.#.u: https://www.fmvz.unam.mx/

650.#.4.x: Biotecnología y Ciencias Agropecuarias

336.#.#.b: article

336.#.#.3: Artículo de Investigación

336.#.#.a: Artículo

351.#.#.6: https://veterinariamexico.fmvz.unam.mx/index.php/vet/index

351.#.#.b: Veterinaria México OA

351.#.#.a: Artículos

harvesting_group: RevistasUNAM

270.1.#.p: Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

590.#.#.c: Open Journal Systems (OJS)

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270.1.#.d: México

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883.#.#.u: https://revistas.unam.mx/catalogo/

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883.#.#.1: https://www.publicaciones.unam.mx/

883.#.#.q: Dirección General de Publicaciones y Fomento Editorial

850.#.#.a: Universidad Nacional Autónoma de México

856.4.0.u: https://veterinariamexico.fmvz.unam.mx/index.php/vet/article/view/441/512

100.1.#.a: Serrato López, Ana G.; Montesinos Montesinos, Juan J.; Anzaldúa Arce, Santiago R.

524.#.#.a: Serrato López, et al. (2017). The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine. Veterinaria México OA; Vol. 4 Núm. 3, 2017. Recuperado de https://repositorio.unam.mx/contenidos/60420

245.1.0.a: The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine

502.#.#.c: Universidad Nacional Autónoma de México

561.1.#.a: Facultad de Medicina Veterinaria y Zootecnia, UNAM

264.#.0.c: 2017

264.#.1.c: 2017-09-04

653.#.#.a: Uterus; mesenchymal stem cells; regenerative medicine; immune modulation; veterinary medicine

506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY 4.0 Internacional, https://creativecommons.org/licenses/by/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico vetmexicooa@gmail.com

884.#.#.k: https://veterinariamexico.fmvz.unam.mx/index.php/vet/article/view/441

001.#.#.#: 131.oai:ojs.pkp.sfu.ca:article/441

041.#.7.h: eng

520.3.#.a: Mesenchymal stem cells (mscs) have been isolated from the endometrium of humans, mice, cows, pigs and ewes. typically, these cells are detected in the deep regions of the endometrium, closer to the union with the myometrium. mscs possess characteristics such as clonogenicity and multipotentiality since they can differentiate in vitro into adipogenic, chondrogenic and osteogenic lineages. these cells can be induced to differentiate in vitro not only into the mesodermal lineage but also into the endodermal and ectodermal lineages. therefore, mscs show a great regenerative capacity for various organs and tissues, including the endometrium. some advantages of endometrial mscs compared with other msc sources are their immune modulating activity, their ease of obtainment, and the amount of sample that may be collected. The study of endometrial mscs in domestic animals is a new and promising field because increasing our understanding of the physiology and biology of these cells may lead to a better understanding of the physiopathology of reproductive diseases, and the development of treatment methods for infertility problems. in other veterinary medicine fields, mscs can be used for the treatment of autoimmune diseases, cardiac affections, musculoskeletal and articular lesions, muscle degeneration, type 1 diabetes, urinary tract diseases, neurodegenerative processes and tumours. finally, mscs are also an important clinical tool for tissue engineering and regenerative medicine. The aim of this review is to present an updated outlook of the knowledge regarding endometrial mscs and their possible applications in veterinary medicine.figure 1 immunoregulatory ability of mscs. mscs regulate the functions of nk cells, dendritic cells (dc) and t lymphocytes. The immunosuppressive effect may occur through the secretion of different factors or through cellular contact (black arrows). The former pathway involves tgfß, hgf, il-10, pge2, and hla-g5, whereas the latter pathway involves the products of ido enzyme activity, pd-l1, hla-g1, icam-i and vcam-i. pro-inflammatory cytokines (ifn-?) secreted by nk cells and activated t lymphocytes favour the immunoregulatory activity of mscs (dotted lines), because they increase or induce the secretion of molecules that regulate the functions of the distinct cellular components of the immune system. modified from montesinos et al, and ma et al.19,66

773.1.#.t: Veterinaria México OA; Vol. 4 Núm. 3 (2017)

773.1.#.o: https://veterinariamexico.fmvz.unam.mx/index.php/vet/index

022.#.#.a: ISSN electrónico: 2448-6760

310.#.#.a: Trimestral

264.#.1.b: Facultad de Medicina Veterinaria y Zootecnia, UNAM

doi: https://doi.org/10.21753/vmoa.4.3.441

harvesting_date: 2023-11-08 13:10:00.0

856.#.0.q: application/pdf

245.1.0.b: The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine

last_modified: 2023-11-08 13:00:00

license_url: https://creativecommons.org/licenses/by/4.0/legalcode.es

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Artículo

The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine

Serrato López, Ana G.; Montesinos Montesinos, Juan J.; Anzaldúa Arce, Santiago R.

Facultad de Medicina Veterinaria y Zootecnia, UNAM, publicado en Veterinaria México OA, y cosechado de Revistas UNAM

Licencia de uso

Procedencia del contenido

Entidad o dependencia
Facultad de Medicina Veterinaria y Zootecnia, UNAM
Revista
Repositorio
Contacto
Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

Cita

Serrato López, et al. (2017). The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine. Veterinaria México OA; Vol. 4 Núm. 3, 2017. Recuperado de https://repositorio.unam.mx/contenidos/60420

Descripción del recurso

Autor(es)
Serrato López, Ana G.; Montesinos Montesinos, Juan J.; Anzaldúa Arce, Santiago R.
Tipo
Artículo de Investigación
Área del conocimiento
Biotecnología y Ciencias Agropecuarias
Título
The endometrium as a source of mesenchymal stem cells in domestic animals and possible applications in veterinary medicine
Fecha
2017-09-04
Resumen
Mesenchymal stem cells (mscs) have been isolated from the endometrium of humans, mice, cows, pigs and ewes. typically, these cells are detected in the deep regions of the endometrium, closer to the union with the myometrium. mscs possess characteristics such as clonogenicity and multipotentiality since they can differentiate in vitro into adipogenic, chondrogenic and osteogenic lineages. these cells can be induced to differentiate in vitro not only into the mesodermal lineage but also into the endodermal and ectodermal lineages. therefore, mscs show a great regenerative capacity for various organs and tissues, including the endometrium. some advantages of endometrial mscs compared with other msc sources are their immune modulating activity, their ease of obtainment, and the amount of sample that may be collected. The study of endometrial mscs in domestic animals is a new and promising field because increasing our understanding of the physiology and biology of these cells may lead to a better understanding of the physiopathology of reproductive diseases, and the development of treatment methods for infertility problems. in other veterinary medicine fields, mscs can be used for the treatment of autoimmune diseases, cardiac affections, musculoskeletal and articular lesions, muscle degeneration, type 1 diabetes, urinary tract diseases, neurodegenerative processes and tumours. finally, mscs are also an important clinical tool for tissue engineering and regenerative medicine. The aim of this review is to present an updated outlook of the knowledge regarding endometrial mscs and their possible applications in veterinary medicine.figure 1 immunoregulatory ability of mscs. mscs regulate the functions of nk cells, dendritic cells (dc) and t lymphocytes. The immunosuppressive effect may occur through the secretion of different factors or through cellular contact (black arrows). The former pathway involves tgfß, hgf, il-10, pge2, and hla-g5, whereas the latter pathway involves the products of ido enzyme activity, pd-l1, hla-g1, icam-i and vcam-i. pro-inflammatory cytokines (ifn-?) secreted by nk cells and activated t lymphocytes favour the immunoregulatory activity of mscs (dotted lines), because they increase or induce the secretion of molecules that regulate the functions of the distinct cellular components of the immune system. modified from montesinos et al, and ma et al.19,66
Tema
Uterus; mesenchymal stem cells; regenerative medicine; immune modulation; veterinary medicine
Idioma
eng
ISSN
ISSN electrónico: 2448-6760

Enlaces