dor_id: 22829
506.#.#.a: Público
590.#.#.d: Los artículos enviados a la "Revista Internacional de Contaminación Ambiental" se juzgan por medio de un proceso de revisión por pares
510.0.#.a: Consejo Nacional de Ciencia y Tecnología (CONACyT); Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal (Latindex); Scientific Electronic Library Online (SciELO); SCOPUS, Web Of Science (WoS); Aquatic Sciences and Fisheries Abstracts, Cab Abstracts, Cab Health, Chemical Abstracts, Elsevier Biobase, Elsevier Geo Abstracts, Periódica, Pollution Abstracts, SCOPUS, Water Resources Abstracts
561.#.#.u: https://www.atmosfera.unam.mx/
650.#.4.x: Biología y Química
336.#.#.b: article
336.#.#.3: Artículo de Investigación
336.#.#.a: Artículo
351.#.#.6: https://www.revistascca.unam.mx/rica/index.php/rica/index
351.#.#.b: Revista Internacional de Contaminación Ambiental
351.#.#.a: Artículos
harvesting_group: RevistasUNAM
270.1.#.p: Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx
590.#.#.c: Open Journal Systems (OJS)
270.#.#.d: MX
270.1.#.d: México
590.#.#.b: Concentrador
883.#.#.u: https://revistas.unam.mx/catalogo/
883.#.#.a: Revistas UNAM
590.#.#.a: Coordinación de Difusión Cultural
883.#.#.1: https://www.publicaciones.unam.mx/
883.#.#.q: Dirección General de Publicaciones y Fomento Editorial
850.#.#.a: Universidad Nacional Autónoma de México
856.4.0.u: https://www.revistascca.unam.mx/rica/index.php/rica/article/view/RICA.2017.33.04.01/46710
100.1.#.a: Rodeiro Guerra, Idania; Hernández Ojeda, Sandra Luz; Herrera Isidrón, José Alfredo; Hernández Balmaseda, Ivones; Padrón Yaquis, Saúl; Olguín Reyes, Sitlali del Rosario; Alejo Rodríguez, Pedro Luis; Ronquillo Sánchez, María Dolores; Camacho Carranza, Rafael; Menéndez Soto del Valle, Roberto; Fernández Pérez, Miguel David; Espinosa Aguirre, Jesús Javier
524.#.#.a: Rodeiro Guerra, Idania, et al. (2017). STUDY OF THE INTERACTION OF AN EXTRACT OBTAINED FROM THE MARINE PLANT Thalassia testudinum WITH PHASE I METABOLISM IN RATS. Revista Internacional de Contaminación Ambiental; Vol. 33 Núm. 4, 2017; 547-557. Recuperado de https://repositorio.unam.mx/contenidos/22829
245.1.0.a: STUDY OF THE INTERACTION OF AN EXTRACT OBTAINED FROM THE MARINE PLANT Thalassia testudinum WITH PHASE I METABOLISM IN RATS
502.#.#.c: Universidad Nacional Autónoma de México
561.1.#.a: Instituto de Ciencias de la Atmósfera y Cambio Climático, UNAM
264.#.0.c: 2017
264.#.1.c: 2017-10-30
653.#.#.a: cytochrome P450; drug-interactions; theophylline; benzo[a]pyrene
506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY-NC 4.0 Internacional, https://creativecommons.org/licenses/by-nc/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico claudio.amescua@atmosfera.unam.mx
884.#.#.k: https://www.revistascca.unam.mx/rica/index.php/rica/article/view/RICA.2017.33.04.01
001.#.#.#: 105.oai:ojs.pkp.sfu.ca:article/52286
041.#.7.h: eng
520.3.#.a: The effects of an extract from the marine plant Thalassia testudinum on rat liver cytochrome P450s were investigated. Male Wistar rats were administered for 10 days with 20, 200 or 400 mg/kg oral doses of the extract. The activities of CYP1A1/A2, CYP2B1/B2, CYP2E1 and CYP3A were evaluated. CYP1A1 activity and protein content increased after 200 mg/kg of the extract but mRNA levels remain unchanged. The activity of other CYP isoforms did not change. The S9 fraction derived from the livers of the rats treated with the extract was used to evaluate the effects of this product on the mutagenic activation of benzo[a]pyrene. The number of Salmonella mutant colonies induced by benzo[a]pyrene in the presence of S9 obtained from animals treated with 200 and 400 mg/kg of the extract were respectively 1.8 and 2.3-fold higher than controls, while it was reduced at the 20 mg/kg dose. This strongly support the idea that the extract modulated the liver enzymes which transform benzo[a]pyrene into mutagenic metabolites. Another set of male rats were treated for 10 days with the same doses. Sixteen hours later, rats received oral doses of theophylline (10 mg/kg), blood samples were extracted from each animal at 0, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 12 and 24 h after administration and plasma theophylline concentration was measured. Pre-treatment with the extract increased theophylline clearance. Our results suggested that the extract modify CYP1A in vivo activity and metabolism-based pharmacokinetic interactions between the extract and CYP1A substrates may occur in vivo.
773.1.#.t: Revista Internacional de Contaminación Ambiental; Vol. 33 Núm. 4 (2017); 547-557
773.1.#.o: https://www.revistascca.unam.mx/rica/index.php/rica/index
022.#.#.a: ISSN impreso: 0188-4999
310.#.#.a: Trimestral
300.#.#.a: Páginas: 547-557
264.#.1.b: Instituto de Ciencias de la Atmósfera y Cambio Climático, UNAM
doi: https://doi.org/10.20937/RICA.2017.33.04.01
harvesting_date: 2023-11-08 13:10:00.0
856.#.0.q: application/pdf
last_modified: 2024-03-19 14:00:00
license_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode.es
license_type: by-nc
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