dor_id: 22829

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650.#.4.x: Biología y Química

336.#.#.b: article

336.#.#.3: Artículo de Investigación

336.#.#.a: Artículo

351.#.#.6: https://www.revistascca.unam.mx/rica/index.php/rica/index

351.#.#.b: Revista Internacional de Contaminación Ambiental

351.#.#.a: Artículos

harvesting_group: RevistasUNAM

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856.4.0.u: https://www.revistascca.unam.mx/rica/index.php/rica/article/view/RICA.2017.33.04.01/46710

100.1.#.a: Rodeiro Guerra, Idania; Hernández Ojeda, Sandra Luz; Herrera Isidrón, José Alfredo; Hernández Balmaseda, Ivones; Padrón Yaquis, Saúl; Olguín Reyes, Sitlali del Rosario; Alejo Rodríguez, Pedro Luis; Ronquillo Sánchez, María Dolores; Camacho Carranza, Rafael; Menéndez Soto del Valle, Roberto; Fernández Pérez, Miguel David; Espinosa Aguirre, Jesús Javier

524.#.#.a: Rodeiro Guerra, Idania, et al. (2017). STUDY OF THE INTERACTION OF AN EXTRACT OBTAINED FROM THE MARINE PLANT Thalassia testudinum WITH PHASE I METABOLISM IN RATS. Revista Internacional de Contaminación Ambiental; Vol. 33 Núm. 4, 2017; 547-557. Recuperado de https://repositorio.unam.mx/contenidos/22829

245.1.0.a: STUDY OF THE INTERACTION OF AN EXTRACT OBTAINED FROM THE MARINE PLANT Thalassia testudinum WITH PHASE I METABOLISM IN RATS

502.#.#.c: Universidad Nacional Autónoma de México

561.1.#.a: Instituto de Ciencias de la Atmósfera y Cambio Climático, UNAM

264.#.0.c: 2017

264.#.1.c: 2017-10-30

653.#.#.a: cytochrome P450; drug-interactions; theophylline; benzo[a]pyrene

506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY-NC 4.0 Internacional, https://creativecommons.org/licenses/by-nc/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico claudio.amescua@atmosfera.unam.mx

884.#.#.k: https://www.revistascca.unam.mx/rica/index.php/rica/article/view/RICA.2017.33.04.01

001.#.#.#: 105.oai:ojs.pkp.sfu.ca:article/52286

041.#.7.h: eng

520.3.#.a: The effects of an extract from the marine plant Thalassia testudinum on rat liver cytochrome P450s were investigated. Male Wistar rats were administered for 10 days with 20, 200 or 400 mg/kg oral doses of the extract. The activities of CYP1A1/A2, CYP2B1/B2, CYP2E1 and CYP3A were evaluated. CYP1A1 activity and protein content increased after 200 mg/kg of the extract but mRNA levels remain unchanged. The activity of other CYP isoforms did not change. The S9 fraction derived from the livers of the rats treated with the extract was used to evaluate the effects of this product on the mutagenic activation of benzo[a]pyrene. The number of Salmonella mutant colonies induced by benzo[a]pyrene in the presence of S9 obtained from animals treated with 200 and 400 mg/kg of the extract were respectively 1.8 and 2.3-fold higher than controls, while it was reduced at the 20 mg/kg dose. This strongly support the idea that the extract modulated the liver enzymes which transform benzo[a]pyrene into mutagenic metabolites. Another set of male rats were treated for 10 days with the same doses. Sixteen hours later, rats received oral doses of theophylline (10 mg/kg), blood samples were extracted from each animal at 0, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 12 and 24 h after administration and plasma theophylline concentration was measured. Pre-treatment with the extract increased theophylline clearance. Our results suggested that the extract modify CYP1A in vivo activity and metabolism-based pharmacokinetic interactions between the extract and CYP1A substrates may occur in vivo.

773.1.#.t: Revista Internacional de Contaminación Ambiental; Vol. 33 Núm. 4 (2017); 547-557

773.1.#.o: https://www.revistascca.unam.mx/rica/index.php/rica/index

022.#.#.a: ISSN impreso: 0188-4999

310.#.#.a: Trimestral

300.#.#.a: Páginas: 547-557

264.#.1.b: Instituto de Ciencias de la Atmósfera y Cambio Climático, UNAM

doi: https://doi.org/10.20937/RICA.2017.33.04.01

harvesting_date: 2023-11-08 13:10:00.0

856.#.0.q: application/pdf

last_modified: 2024-03-19 14:00:00

license_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode.es

license_type: by-nc

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No entro en nada

No entro en nada 2

Artículo

STUDY OF THE INTERACTION OF AN EXTRACT OBTAINED FROM THE MARINE PLANT Thalassia testudinum WITH PHASE I METABOLISM IN RATS

Rodeiro Guerra, Idania; Hernández Ojeda, Sandra Luz; Herrera Isidrón, José Alfredo; Hernández Balmaseda, Ivones; Padrón Yaquis, Saúl; Olguín Reyes, Sitlali del Rosario; Alejo Rodríguez, Pedro Luis; Ronquillo Sánchez, María Dolores; Camacho Carranza, Rafael; Menéndez Soto del Valle, Roberto; Fernández Pérez, Miguel David; Espinosa Aguirre, Jesús Javier

Instituto de Ciencias de la Atmósfera y Cambio Climático, UNAM, publicado en Revista Internacional de Contaminación Ambiental, y cosechado de Revistas UNAM

Licencia de uso

Procedencia del contenido

Cita

Rodeiro Guerra, Idania, et al. (2017). STUDY OF THE INTERACTION OF AN EXTRACT OBTAINED FROM THE MARINE PLANT Thalassia testudinum WITH PHASE I METABOLISM IN RATS. Revista Internacional de Contaminación Ambiental; Vol. 33 Núm. 4, 2017; 547-557. Recuperado de https://repositorio.unam.mx/contenidos/22829

Descripción del recurso

Autor(es)
Rodeiro Guerra, Idania; Hernández Ojeda, Sandra Luz; Herrera Isidrón, José Alfredo; Hernández Balmaseda, Ivones; Padrón Yaquis, Saúl; Olguín Reyes, Sitlali del Rosario; Alejo Rodríguez, Pedro Luis; Ronquillo Sánchez, María Dolores; Camacho Carranza, Rafael; Menéndez Soto del Valle, Roberto; Fernández Pérez, Miguel David; Espinosa Aguirre, Jesús Javier
Tipo
Artículo de Investigación
Área del conocimiento
Biología y Química
Título
STUDY OF THE INTERACTION OF AN EXTRACT OBTAINED FROM THE MARINE PLANT Thalassia testudinum WITH PHASE I METABOLISM IN RATS
Fecha
2017-10-30
Resumen
The effects of an extract from the marine plant Thalassia testudinum on rat liver cytochrome P450s were investigated. Male Wistar rats were administered for 10 days with 20, 200 or 400 mg/kg oral doses of the extract. The activities of CYP1A1/A2, CYP2B1/B2, CYP2E1 and CYP3A were evaluated. CYP1A1 activity and protein content increased after 200 mg/kg of the extract but mRNA levels remain unchanged. The activity of other CYP isoforms did not change. The S9 fraction derived from the livers of the rats treated with the extract was used to evaluate the effects of this product on the mutagenic activation of benzo[a]pyrene. The number of Salmonella mutant colonies induced by benzo[a]pyrene in the presence of S9 obtained from animals treated with 200 and 400 mg/kg of the extract were respectively 1.8 and 2.3-fold higher than controls, while it was reduced at the 20 mg/kg dose. This strongly support the idea that the extract modulated the liver enzymes which transform benzo[a]pyrene into mutagenic metabolites. Another set of male rats were treated for 10 days with the same doses. Sixteen hours later, rats received oral doses of theophylline (10 mg/kg), blood samples were extracted from each animal at 0, 0.25, 0.5, 1, 2, 3, 4, 6, 8, 12 and 24 h after administration and plasma theophylline concentration was measured. Pre-treatment with the extract increased theophylline clearance. Our results suggested that the extract modify CYP1A in vivo activity and metabolism-based pharmacokinetic interactions between the extract and CYP1A substrates may occur in vivo.
Tema
cytochrome P450; drug-interactions; theophylline; benzo[a]pyrene
Idioma
eng
ISSN
ISSN impreso: 0188-4999

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