La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY 4.0 Internacional, https://creativecommons.org/licenses/by/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico vetmexicooa@fmvz.unam.mx.
Ver términos de la licencia
Facultad de Medicina Veterinaria y Zootecnia, UNAM
Revista
Repositorio
Contacto
Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx
Autor(es)
Quesada López, Tania; Villarroya, Francesc
Tipo
Artículo de Investigación
Área del conocimiento
Biotecnología y Ciencias Agropecuarias
Título
Obesity and thermogenic adipose tissue plasticity in dogs
Fecha
2023-06-21
Resumen
Obesity in pet dogs is a growing concern in veterinary medicine in developed countries. Obesity is associated with the expansion of white fat, the main tissue that stores metabolic energy in mammals. Brown and beige adipose tissues, which express thermogenic uncoupling protein-1, are oppositely related to obesity due to their thermogenic activity and associated energy expenditure properties. Dogs possess high amounts of brown adipose tissue early after birth; however, its involution with aging causes adult dogs to possess minimal active brown fat. However, adult dogs retain a remarkable capacity to activate the browning of adipose tissue depots in response to sustained β-adrenergic stimulation or other inducers, such as cannabinoid receptor-1 inhibitors. Therefore, dogs retain the capacity of adipose tissue plasticity to acquire thermogenic properties, which should be considered when developing obesity prevention and/or treatment strategies for dogs.
Tema
Dogs; Obesity; Brown Adipose Tissue; Beige Adipose Tissue; Β-adrenergic Receptors; Animal Nutrition; Perros, Obesidad, Tejido Adiposo Marrón, Tejido Adiposo Beige, Receptores Β-adrenérgicos
Idioma
eng
ISSN
ISSN electrónico: 2448-6760
