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Ver términos de la licenciaGonzález González, Ulises, et al. (2024). O-GlcNAcylation and Adhesion Molecules in Carcinomas. TIP Revista Especializada en Ciencias Químico-Biológicas; Vol. 27, 2024. Recuperado de https://repositorio.unam.mx/contenidos/4160899
Autor(es)
González González, Ulises; Jiménez Castillo, Victoria; Calvo Ramírez, Jocelyne del Rosario; Ramírez Thomé, Saira Karina; Ávila Curiel, Beatriz Xóchitl; Hernández Juárez, Jesús; Herrera Cruz, Mariana; Díaz Castillejos, Risk; Solórzano Mata, Carlos Josué
Tipo
Artículo de Investigación
Área del conocimiento
Biología y Química
Título
O-GlcNAcylation and Adhesion Molecules in Carcinomas
Fecha
2024-05-22
Resumen
O-GlcNAcylation is a post-translational modification sensitive to the nutritional state of the cell, in which a residue of N-acetyl-D-glucosamine is added to the hydroxyl group of serine or threonine in proteins from the substrate UDP-GlcNAc by O-GlcNAc transferase and, eliminated by O-GlcNAcase. Its importance lies in its ability to regulate different cellular events such as cellular metabolism, proliferation, resistance to cell death, growth and signaling pathways, which together have a positive impact on transformation and tumor progression. O-GlcNAcylation have been found in various carcinomas to modify the expression levels of adhesion molecules favoring the process of migration and metastasis. This review discusses the mechanism of O-GlcNAcylation and its impact on cellular adhesion in carcinomas, as well as other research directions.
Tema
O-GlcNAcylation; glycosylation; carcinoma; adhesion molecules; metastasis; O-GlcNAcilación; glicosilación; carcinoma; moléculas de adhesión; metástasis
Idioma
spa
ISSN
ISSN electrónico: 2395-8723; ISSN impreso: 1405-888X
