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Centro de Investigaciones Interdisciplinarias en Ciencias y Humanidades, UNAM; Instituto de Ciencias Aplicadas y Tecnología, UNAM; Centro de Nanociencias y Nanotecnología, UNAM
Revista
Repositorio
Contacto
Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx
Ortega Galindo, Ana Saret, et al. (2023). Liposomes in nanomedicine: from concept to current clinical applications and research trends. Mundo Nano. Revista Interdisciplinaria en Nanociencias y Nanotecnología; Vol. 16 Núm. 31, 2023: 2do semestre / Nanomateriales avanzados: desde la síntesis hasta la innovación tecnológica; 1e-26e. Recuperado de https://repositorio.unam.mx/contenidos/4147799
Autor(es)
Ortega Galindo, Ana Saret; Díaz Peralta, Lucero; Galván Hernández, Arturo; Ortega Blake, Iván; Pérez Riascos, Alejandro; Rojas Aguirre, Yareli
Tipo
Artículo de Investigación
Área del conocimiento
Multidisciplina
Título
Liposomes in nanomedicine: from concept to current clinical applications and research trends
Fecha
2023-05-14
Resumen
Liposomes are biocompatible and biodegradable artificial vesicles with a two-compartment structure that can encapsulate both hydrophilic and lipophilic molecules. Liposomes have been extensively studied over the last twenty years, leading to the development of several promising technologies including Stealth® and DepoFoam® liposomes. Also targeted, physicochemical stimuli-responsive, and liposomal-based combined therapies have evolved. Liposomes are the first nanomedicines to reach the clinical use. Currently, up to 20 different liposomal technologies are commercially available, and approximately 18 liposomal formulations are in clinical trials. While most commercial liposomes are used to treat cancer, there are some liposomal developments that have shown promising results for treating other diseases. In this review, we present an overview of the basic concepts of liposomes, breakthroughs in liposomal-based nanoformulations in clinical trials and currently marketed liposomal technologies. Furthermore, using data science tools, we present a comprehensive analysis of current research in liposomes. Undoubtedly, liposomes will continue to be at the forefront of nanotechnologies applied for the benefit of human health.
Idioma
spa
ISSN
ISSN electrónico: 2448-5691; ISSN impreso: 2007-5979
