dor_id: 58877

506.#.#.a: Público

590.#.#.d: Los artículos enviados a la revista "INTERdisciplina", se juzgan por medio de un proceso de revisión por pares

510.0.#.a: Consejo Nacional de Ciencia y Tecnología (CONACyT); Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal (Latindex); Scientific Electronic Library Online (SciELO)

561.#.#.u: https://www.ceiich.unam.mx/0/index.php

650.#.4.x: Multidisciplina

336.#.#.b: article

336.#.#.3: Artículo de Investigación

336.#.#.a: Artículo

351.#.#.6: https://www.revistas.unam.mx/index.php/inter/index

351.#.#.b: INTERdisciplina

351.#.#.a: Artículos

harvesting_group: RevistasUNAM

270.1.#.p: Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

590.#.#.c: Open Journal Systems (OJS)

270.#.#.d: MX

270.1.#.d: México

590.#.#.b: Concentrador

883.#.#.u: https://revistas.unam.mx/catalogo/

883.#.#.a: Revistas UNAM

590.#.#.a: Coordinación de Difusión Cultural

883.#.#.1: https://www.publicaciones.unam.mx/

883.#.#.q: Dirección General de Publicaciones y Fomento Editorial

850.#.#.a: Universidad Nacional Autónoma de México

856.4.0.u: https://www.revistas.unam.mx/index.php/inter/article/view/47627/42841

100.1.#.a: Dávila-velderrain, José; Álvarez-buylla Roces, Elena

524.#.#.a: Dávila-velderrain, José, et al. (2015). Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption. INTER DISCIPLINA; Vol. 3 Núm. 5, 2015: Evolucionismo. Recuperado de https://repositorio.unam.mx/contenidos/58877

245.1.0.a: Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption

502.#.#.c: Universidad Nacional Autónoma de México

561.1.#.a: Centro de Investigaciones Interdisciplinarias en Ciencias y Humanidades, UNAM

264.#.0.c: 2015

264.#.1.c: 2015-02-04

506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY-NC-ND 4.0 Internacional, https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico rev.interd@unam.mx

884.#.#.k: https://www.revistas.unam.mx/index.php/inter/article/view/47627

001.#.#.#: 068.oai:ojs.pkp.sfu.ca:article/47627

041.#.7.h: spa

520.3.#.a: In this essay we question the validity of basic assumptions in molecular biology and evolution on the basis of recent experimental data and through the lenses of a systems and nonlinear perspective. We focus our discussion on two well-established foundations of biology: the flow of information in molecular biology (i.e., the central dogma of molecular biology), and the “causal” linear signaling pathway paradigm.Under both paradigms the subliminal assumption of a one-to-one genotype-phenotype mapping (GPM) constitutes an underlying working hypothesis in many cases. We ask if this is empirically sustainable in post-genomic biology. We conclude that when embracing the notion of complex networks and dynamical processes governing cellular behavior — a view now empirically validated — one-to-one mapping can no longer be sustained. We hypothesize that such subliminal and sometimes explicit assumption may be upheld, to a certain degree, because it is convenient for the private appropriation and marketing of scientific discoveries. Hopefully, our discussion will help smooth the undergoing transition towards a more integrative, explanatory, quantitative and multidisciplinary systems biology. The latter will likely also yield more preventive and sustainable medical and agricultural developments, respectively, than a reductionist approach.

773.1.#.t: INTER DISCIPLINA; Vol. 3 Núm. 5 (2015): Evolucionismo

773.1.#.o: https://www.revistas.unam.mx/index.php/inter/index

022.#.#.a: ISSN: 2395-969X; ISSN electrónico: 2448-5705

310.#.#.a: Cuatrimestral

264.#.1.b: Centro de Investigaciones Interdisciplinarias en Ciencias y Humanidades, UNAM

doi: https://doi.org/10.22201/ceiich.24485705e.2015.5.47627

handle: 008a1fb25e308c2d

harvesting_date: 2023-08-23 17:00:00.0

856.#.0.q: application/pdf

245.1.0.b: Linear Causation Schemes in Post-genomic Biology: The Subliminal and Convenient One-to-one Genotype-Phenotype Mapping Assumption

last_modified: 2023-08-23 17:00:00

license_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.es

license_type: by-nc-nd

_deleted_conflicts: 2-ca3ded897b86c83017479a7e12ddd3b6

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