dor_id: 43298

506.#.#.a: Público

590.#.#.d: si

510.0.#.a: Consejo Nacional de Ciencia y Tecnología (CONACyT), Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal (Latindex), Scientific Electronic Library Online (SciELO)

561.#.#.u: http://www.odonto.unam.mx/

561.#.#.a: Facultad de Odontología, UNAM

650.#.4.x: Medicina y Ciencias de la Salud

336.#.#.b: article

336.#.#.3: Artículo Técnico-Profesional

336.#.#.a: Artículo

351.#.#.6: http://revistas.unam.mx/index.php/rom

351.#.#.b: Revista Odontológica Mexicana

351.#.#.a: Artículos

harvesting_group: RevistasUNAM

270.1.#.p: Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

590.#.#.c: Open Journal Systems (OJS)

270.#.#.d: MX

270.1.#.d: México

590.#.#.b: Concentrador

883.#.#.u: http://www.revistas.unam.mx/front/

883.#.#.a: Revistas UNAM

590.#.#.a: Coordinación de Difusión Cultural, UNAM

883.#.#.1: https://www.publicaciones.unam.mx/

883.#.#.q: Dirección General de Publicaciones y Fomento Editorial, UNAM

850.#.#.a: Universidad Nacional Autónoma de México

856.4.0.u: http://revistas.unam.mx/index.php/rom/article/view/57722/51163

100.1.#.a: Figueroa Avendaño, Jenniffer; Rodríguez Farías, Rebeca; Acero Mondragón, Edward; Salazar Hernández, Martha

524.#.#.a: Figueroa Avendaño, Jenniffer, et al. (2016). Histological correlation of Ki-67 and D1 cycline markers expression in squamous cell carcinoma in the oral cavity. Revista Odontológica Mexicana; Vol 20, No 4-ING. Recuperado de https://repositorio.unam.mx/contenidos/43298

245.1.0.a: Histological correlation of Ki-67 and D1 cycline markers expression in squamous cell carcinoma in the oral cavity

502.#.#.c: Universidad Nacional Autónoma de México

561.1.#.a: Facultad de Odontología, UNAM

264.#.0.c: 2016

264.#.1.c: 2017-01-26

506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY-NC-ND 4.0 Internacional, https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.es, fecha de asignación de la licencia 2017-01-26, para un uso diferente consultar al responsable jurídico del repositorio por medio de danyelacarmona@gmail.com

884.#.#.k: http://revistas.unam.mx/index.php/rom/article/view/57722

041.#.7.h: eng

520.3.#.a: Introduction: Oral squamous cell carcinoma (OSCC) is a malignant neoplasia originated in the epithelium’s keratocytes. Early biopsies reveal dysplastic mitotic keratocytes and sub-epithelial infl ammatory infiltrate which progress towards a loss of basal membrane. Nevertheless, hematoxillin and eosin (H&E) histological diagnosis does not show suitable clinical correlation; this aspect improves when molecular markers such as Ki-67 and cyclin D1 are used. The aim of the present study was to correlate histological description of OSCC cases with Ki-676 and cyclin D1 expression. Material and methods: Twelve patients with lesions suggestive of oral cancer were analyzed, patients with OSCC diagnosis were included in the study. Single biopsies were taken, observing histological and technical processing for paraffin cuts, coloration with H&E and immunohistochemical coloration with cyclin D1 and Ki-67. Three patients met inclusion criteria, they were named C1, C2 and C3. OSCC type was classifi ed according to the American Joint Committee on Cancer. Results: Histologically, C1 case was classifi ed as type II OSCC. Cases C2 and C3 were classifi ed as type I OSCC. Immunohistochemical analysis for C1 revealed Ki-67 positive and cyclin D1 negative; C2 exhibited Ki-67 negative and cyclin D1 positive, and C3 showed Ki-67 positive and cyclin D1 negative. Conclusions: Search for markers such as Ki-67 and cyclin D1 in pre-established OSCC diagnoses can influence histological results, contributing thus to more accurate diagnosis and treatment for the patients.

773.1.#.t: Revista Odontológica Mexicana; Vol 20, No 4-ING

022.#.#.a: ISSN: 1870-199X

264.#.1.b: Facultad de Odontología, UNAM

758.#.#.1: http://revistas.unam.mx/index.php/rom/index

handle: 00ac8f1d91ce4f70

harvesting_date: 2019-02-06 00:00:00.0

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last_modified: 2022-11-11 19:00:00

license_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.es

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Artículo

Histological correlation of Ki-67 and D1 cycline markers expression in squamous cell carcinoma in the oral cavity

Figueroa Avendaño, Jenniffer; Rodríguez Farías, Rebeca; Acero Mondragón, Edward; Salazar Hernández, Martha

Facultad de Odontología, UNAM, publicado en Revista Odontológica Mexicana, y cosechado de Revistas UNAM

Licencia de uso

Procedencia del contenido

Entidad o dependencia
Facultad de Odontología, UNAM
Revista
Revista Odontológica Mexicana
Repositorio
Revistas UNAM
Contacto
Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

Cita

Figueroa Avendaño, Jenniffer, et al. (2016). Histological correlation of Ki-67 and D1 cycline markers expression in squamous cell carcinoma in the oral cavity. Revista Odontológica Mexicana; Vol 20, No 4-ING. Recuperado de https://repositorio.unam.mx/contenidos/43298

Descripción del recurso

Autor(es)
Figueroa Avendaño, Jenniffer; Rodríguez Farías, Rebeca; Acero Mondragón, Edward; Salazar Hernández, Martha
Tipo
Artículo Técnico-Profesional
Área del conocimiento
Medicina y Ciencias de la Salud
Título
Histological correlation of Ki-67 and D1 cycline markers expression in squamous cell carcinoma in the oral cavity
Fecha
2017-01-26
Resumen
Introduction: Oral squamous cell carcinoma (OSCC) is a malignant neoplasia originated in the epithelium’s keratocytes. Early biopsies reveal dysplastic mitotic keratocytes and sub-epithelial infl ammatory infiltrate which progress towards a loss of basal membrane. Nevertheless, hematoxillin and eosin (H&E) histological diagnosis does not show suitable clinical correlation; this aspect improves when molecular markers such as Ki-67 and cyclin D1 are used. The aim of the present study was to correlate histological description of OSCC cases with Ki-676 and cyclin D1 expression. Material and methods: Twelve patients with lesions suggestive of oral cancer were analyzed, patients with OSCC diagnosis were included in the study. Single biopsies were taken, observing histological and technical processing for paraffin cuts, coloration with H&E and immunohistochemical coloration with cyclin D1 and Ki-67. Three patients met inclusion criteria, they were named C1, C2 and C3. OSCC type was classifi ed according to the American Joint Committee on Cancer. Results: Histologically, C1 case was classifi ed as type II OSCC. Cases C2 and C3 were classifi ed as type I OSCC. Immunohistochemical analysis for C1 revealed Ki-67 positive and cyclin D1 negative; C2 exhibited Ki-67 negative and cyclin D1 positive, and C3 showed Ki-67 positive and cyclin D1 negative. Conclusions: Search for markers such as Ki-67 and cyclin D1 in pre-established OSCC diagnoses can influence histological results, contributing thus to more accurate diagnosis and treatment for the patients.
Idioma
eng
ISSN
ISSN: 1870-199X

Enlaces