dor_id: 4161120

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650.#.4.x: Biología y Química

336.#.#.b: article

336.#.#.3: Artículo de Investigación

336.#.#.a: Artículo

351.#.#.6: https://www.revistascca.unam.mx/rica/index.php/rica/index

351.#.#.b: Revista Internacional de Contaminación Ambiental

351.#.#.a: Artículos

harvesting_group: RevistasUNAM.105

270.1.#.p: Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

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856.4.0.u: https://www.revistascca.unam.mx/rica/index.php/rica/article/view/55124/47450

100.1.#.a: Moraga, Vicente; Gaete, Hernán

524.#.#.a: Moraga, Vicente, et al. (2024). Evaluación ecotoxicológica de las interacciones entre paracetamol e ibuprofeno sobre la microalga de agua dulce Pseudokirchneriella subcapitata. Revista Internacional de Contaminación Ambiental; Vol. 40, 2024; 495-502. Recuperado de https://repositorio.unam.mx/contenidos/4161120

245.1.0.a: Evaluación ecotoxicológica de las interacciones entre paracetamol e ibuprofeno sobre la microalga de agua dulce Pseudokirchneriella subcapitata

502.#.#.c: Universidad Nacional Autónoma de México

561.1.#.a: Instituto de Ciencias de la Atmósfera y Cambio Climático, UNAM

264.#.0.c: 2024

264.#.1.c: 2024-11-21

653.#.#.a: toxicity; emerging pollutants; pharmaceuticals; microalgae; toxicidad; contaminantes emergentes; fármacos; microalgas

506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY-NC 4.0 Internacional, https://creativecommons.org/licenses/by-nc/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico claudio.amescua@atmosfera.unam.mx

884.#.#.k: https://www.revistascca.unam.mx/rica/index.php/rica/article/view/55124

001.#.#.#: 105.oai:ojs.pkp.sfu.ca:article/55124

041.#.7.h: spa

520.3.#.a: Emerging contaminants, such as drugs for human and veterinary use, are of growing concern due to their potential toxic effects on aquatic organisms. The anti-inflammatories paracetamol and ibuprofen are among the most consumed drugs worldwide and have been found in aquatic ecosystems such as rivers and lakes. The aim of this work was to evaluate the toxicity of paracetamol and ibuprofen and their interactions on the microalga Pseudokirchneriella subcapitata. For this purpose, increasing concentrations of both pharmaceutical compounds were prepared, toxicity bioassays were performed with P. subcapitata, while for interactions, binary mixtures were prepared in the following ratios: 4:1, 1:4, and 1:1 according to the CI20 previously determined. The interactions were determined according to the concentration-addition and synergy-ratio models. The results show that the toxicity of ibuprofen was higher than paracetamol (72-h CI20 of 12.7 and 23.9 mg/L, respectively). The interactions were classified as antagonistic. In conclusion, the results suggest a low environmental risk for primary producers such as the microalgae P. supcapitata, since the concentrations that cause toxic effects are higher than those reported in natural aquatic ecosystems such as lakes and rivers in different parts of the world. On the other hand, the joint presence of both drugs inhibits their individual toxicities on P. subcapitata.

773.1.#.t: Revista Internacional de Contaminación Ambiental; Vol. 40 (2024); 495-502

773.1.#.o: https://www.revistascca.unam.mx/rica/index.php/rica/index

022.#.#.a: ISSN impreso: 0188-4999

310.#.#.a: Trimestral

300.#.#.a: Páginas: 495-502

599.#.#.a: 105

264.#.1.b: Instituto de Ciencias de la Atmósfera y Cambio Climático, UNAM

doi: https://doi.org/10.20937/RICA.55124

harvesting_date: 2025-01-07 00:00:00.0

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245.1.0.b: Ecotoxicological assessment of the interactions between paracetamol and ibuprofen on the freshwater microalgae Pseudokirchneriella subcapitata

last_modified: 2025-01-07 00:00:00

license_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode.es

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Artículo

Evaluación ecotoxicológica de las interacciones entre paracetamol e ibuprofeno sobre la microalga de agua dulce Pseudokirchneriella subcapitata

Moraga, Vicente; Gaete, Hernán

Instituto de Ciencias de la Atmósfera y Cambio Climático, UNAM, publicado en Revista Internacional de Contaminación Ambiental, y cosechado de Revistas UNAM

Licencia de uso

Procedencia del contenido

Cita

Moraga, Vicente, et al. (2024). Evaluación ecotoxicológica de las interacciones entre paracetamol e ibuprofeno sobre la microalga de agua dulce Pseudokirchneriella subcapitata. Revista Internacional de Contaminación Ambiental; Vol. 40, 2024; 495-502. Recuperado de https://repositorio.unam.mx/contenidos/4161120

Descripción del recurso

Autor(es)
Moraga, Vicente; Gaete, Hernán
Tipo
Artículo de Investigación
Área del conocimiento
Biología y Química
Título
Evaluación ecotoxicológica de las interacciones entre paracetamol e ibuprofeno sobre la microalga de agua dulce Pseudokirchneriella subcapitata
Fecha
2024-11-21
Resumen
Emerging contaminants, such as drugs for human and veterinary use, are of growing concern due to their potential toxic effects on aquatic organisms. The anti-inflammatories paracetamol and ibuprofen are among the most consumed drugs worldwide and have been found in aquatic ecosystems such as rivers and lakes. The aim of this work was to evaluate the toxicity of paracetamol and ibuprofen and their interactions on the microalga Pseudokirchneriella subcapitata. For this purpose, increasing concentrations of both pharmaceutical compounds were prepared, toxicity bioassays were performed with P. subcapitata, while for interactions, binary mixtures were prepared in the following ratios: 4:1, 1:4, and 1:1 according to the CI20 previously determined. The interactions were determined according to the concentration-addition and synergy-ratio models. The results show that the toxicity of ibuprofen was higher than paracetamol (72-h CI20 of 12.7 and 23.9 mg/L, respectively). The interactions were classified as antagonistic. In conclusion, the results suggest a low environmental risk for primary producers such as the microalgae P. supcapitata, since the concentrations that cause toxic effects are higher than those reported in natural aquatic ecosystems such as lakes and rivers in different parts of the world. On the other hand, the joint presence of both drugs inhibits their individual toxicities on P. subcapitata.
Tema
toxicity; emerging pollutants; pharmaceuticals; microalgae; toxicidad; contaminantes emergentes; fármacos; microalgas
Idioma
spa
ISSN
ISSN impreso: 0188-4999

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