dor_id: 60553
506.#.#.a: Público
590.#.#.d: Los artículos enviados a la revista "Veterinaria México OA", se juzgan por medio de un proceso de revisión por pares
510.0.#.a: Consejo Nacional de Ciencia y Tecnología (CONACyT); Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal (Latindex); Scientific Electronic Library Online (SciELO); Bibliografía Latinoamericana (Biblat); La Red de Revistas Científicas de América Latina y el Caribe, España y Portugal (Redalyc); Connecting research and researchers (ORCiD)
561.#.#.u: https://www.fmvz.unam.mx/
650.#.4.x: Biotecnología y Ciencias Agropecuarias
336.#.#.b: article
336.#.#.3: Artículo de Investigación
336.#.#.a: Artículo
351.#.#.6: https://veterinariamexico.fmvz.unam.mx/index.php/vet/index
351.#.#.b: Veterinaria México OA
351.#.#.a: Artículos
harvesting_group: RevistasUNAM
270.1.#.p: Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx
590.#.#.c: Open Journal Systems (OJS)
270.#.#.d: MX
270.1.#.d: México
590.#.#.b: Concentrador
883.#.#.u: https://revistas.unam.mx/catalogo/
883.#.#.a: Revistas UNAM
590.#.#.a: Coordinación de Difusión Cultural
883.#.#.1: https://www.publicaciones.unam.mx/
883.#.#.q: Dirección General de Publicaciones y Fomento Editorial
850.#.#.a: Universidad Nacional Autónoma de México
856.4.0.u: https://veterinariamexico.fmvz.unam.mx/index.php/vet/article/view/487/537
100.1.#.a: García Lara, Lucía Gabriela; Morales Martínez, Adriana; Angeles López, Quetzalli Denisse; Pedraza Espitia, Hilda; Pérez Neri, Iván; Rodríguez Balderas, Cesar Augusto; Pérez Severiano, Francisca
524.#.#.a: García Lara, et al. (2018). Establishment and maintenance of an R6/1 transgenic mouse colony and validation of its progressive neurological phenotype to study Huntington’s disease. Veterinaria México OA; Vol. 5 Núm. 1, 2018. Recuperado de https://repositorio.unam.mx/contenidos/60553
245.1.0.a: Establishment and maintenance of an R6/1 transgenic mouse colony and validation of its progressive neurological phenotype to study Huntington’s disease
502.#.#.c: Universidad Nacional Autónoma de México
561.1.#.a: Facultad de Medicina Veterinaria y Zootecnia, UNAM
264.#.0.c: 2018
264.#.1.c: 2018-03-14
653.#.#.a: Huntington’s disease; motor activity; R6/1 transgenic mouse colony; neurodegeneration; motor and behaviour measurements
506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY 4.0 Internacional, https://creativecommons.org/licenses/by/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico vetmexicooa@gmail.com
884.#.#.k: https://veterinariamexico.fmvz.unam.mx/index.php/vet/article/view/487
001.#.#.#: 131.oai:ojs.pkp.sfu.ca:article/487
041.#.7.h: eng
520.3.#.a: Huntington’s disease (hd) is a hereditary neurodegenerative disorder of the central nervous system that mainly affects the basal ganglia and has no cure. The mutation is located at an abnormal expansion of the cag triplet in the huntingtin gene. humans show psychiatric, behavioural and motor disorders. transgenic animal models are essential to the study of hd since the disease only affects humans. therefore, the aim of this article was to describe the formation and maintenance of and to validate the progressive neurological phenotype of an r6/1 transgenic mouse colony. to achieve our objective, the colony founder was imported from jackson laboratories, and the mice were kept under controlled environmental conditions. The animals were bred at the vivarium of the instituto nacional de neurología y neurocirugía manuel velasco suárez. The r6/1 transgenic mice were successfully bred and showed genetic and phenotypic characteristics similar to the ones previously reported. our colony is currently established and validated with the conditions of our vivarium and has produced more than four generations of r6/1 mice. The establishment of the r6/1 colony and its maintenance through generation is an advantage since it allows us to follow the authenticity of the transgenic mice regarding their phenotypic and motor behaviours. furthermore, these animals can be compared with other transgenic mice that reproduce some of the main characteristics of the disease manifested in humans, making these transgenic r6/1 mice a useful tool for the study of hd.figure 2. d) wt mouse with normal fur and weight.
773.1.#.t: Veterinaria México OA; Vol. 5 Núm. 1 (2018)
773.1.#.o: https://veterinariamexico.fmvz.unam.mx/index.php/vet/index
022.#.#.a: ISSN electrónico: 2448-6760
310.#.#.a: Trimestral
264.#.1.b: Facultad de Medicina Veterinaria y Zootecnia, UNAM
doi: https://doi.org/10.21753/vmoa.5.1.487
harvesting_date: 2023-11-08 13:10:00.0
856.#.0.q: application/pdf
last_modified: 2023-11-08 13:00:00
license_url: https://creativecommons.org/licenses/by/4.0/legalcode.es
license_type: by
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