dor_id: 60553

506.#.#.a: Público

590.#.#.d: Los artículos enviados a la revista "Veterinaria México OA", se juzgan por medio de un proceso de revisión por pares

510.0.#.a: Consejo Nacional de Ciencia y Tecnología (CONACyT); Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal (Latindex); Scientific Electronic Library Online (SciELO); Bibliografía Latinoamericana (Biblat); La Red de Revistas Científicas de América Latina y el Caribe, España y Portugal (Redalyc); Connecting research and researchers (ORCiD)

561.#.#.u: https://www.fmvz.unam.mx/

650.#.4.x: Biotecnología y Ciencias Agropecuarias

336.#.#.b: article

336.#.#.3: Artículo de Investigación

336.#.#.a: Artículo

351.#.#.6: https://veterinariamexico.fmvz.unam.mx/index.php/vet/index

351.#.#.b: Veterinaria México OA

351.#.#.a: Artículos

harvesting_group: RevistasUNAM

270.1.#.p: Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

590.#.#.c: Open Journal Systems (OJS)

270.#.#.d: MX

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883.#.#.1: https://www.publicaciones.unam.mx/

883.#.#.q: Dirección General de Publicaciones y Fomento Editorial

850.#.#.a: Universidad Nacional Autónoma de México

856.4.0.u: https://veterinariamexico.fmvz.unam.mx/index.php/vet/article/view/487/537

100.1.#.a: García Lara, Lucía Gabriela; Morales Martínez, Adriana; Angeles López, Quetzalli Denisse; Pedraza Espitia, Hilda; Pérez Neri, Iván; Rodríguez Balderas, Cesar Augusto; Pérez Severiano, Francisca

524.#.#.a: García Lara, et al. (2018). Establishment and maintenance of an R6/1 transgenic mouse colony and validation of its progressive neurological phenotype to study Huntington’s disease. Veterinaria México OA; Vol. 5 Núm. 1, 2018. Recuperado de https://repositorio.unam.mx/contenidos/60553

245.1.0.a: Establishment and maintenance of an R6/1 transgenic mouse colony and validation of its progressive neurological phenotype to study Huntington’s disease

502.#.#.c: Universidad Nacional Autónoma de México

561.1.#.a: Facultad de Medicina Veterinaria y Zootecnia, UNAM

264.#.0.c: 2018

264.#.1.c: 2018-03-14

653.#.#.a: Huntington’s disease; motor activity; R6/1 transgenic mouse colony; neurodegeneration; motor and behaviour measurements

506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY 4.0 Internacional, https://creativecommons.org/licenses/by/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico vetmexicooa@gmail.com

884.#.#.k: https://veterinariamexico.fmvz.unam.mx/index.php/vet/article/view/487

001.#.#.#: 131.oai:ojs.pkp.sfu.ca:article/487

041.#.7.h: eng

520.3.#.a: Huntington’s disease (hd) is a hereditary neurodegenerative disorder of the central nervous system that mainly affects the basal ganglia and has no cure. The mutation is located at an abnormal expansion of the cag triplet in the huntingtin gene. humans show psychiatric, behavioural and motor disorders. transgenic animal models are essential to the study of hd since the disease only affects humans. therefore, the aim of this article was to describe the formation and maintenance of and to validate the progressive neurological phenotype of an r6/1 transgenic mouse colony. to achieve our objective, the colony founder was imported from jackson laboratories, and the mice were kept under controlled environmental conditions. The animals were bred at the vivarium of the instituto nacional de neurología y neurocirugía man­uel velasco suárez. The r6/1 transgenic mice were successfully bred and showed genetic and phenotypic characteristics similar to the ones previously reported. our colony is currently established and validated with the condi­tions of our vivarium and has produced more than four generations of r6/1 mice. The establishment of the r6/1 colony and its maintenance through generation is an advantage since it allows us to follow the authenticity of the transgenic mice regarding their phenotypic and motor behaviours. fur­thermore, these animals can be compared with other transgenic mice that reproduce some of the main characteristics of the disease manifested in hu­mans, making these transgenic r6/1 mice a useful tool for the study of hd.figure 2. d) wt mouse with normal fur and weight.

773.1.#.t: Veterinaria México OA; Vol. 5 Núm. 1 (2018)

773.1.#.o: https://veterinariamexico.fmvz.unam.mx/index.php/vet/index

022.#.#.a: ISSN electrónico: 2448-6760

310.#.#.a: Trimestral

264.#.1.b: Facultad de Medicina Veterinaria y Zootecnia, UNAM

doi: https://doi.org/10.21753/vmoa.5.1.487

harvesting_date: 2023-11-08 13:10:00.0

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last_modified: 2023-11-08 13:00:00

license_url: https://creativecommons.org/licenses/by/4.0/legalcode.es

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Artículo

Establishment and maintenance of an R6/1 transgenic mouse colony and validation of its progressive neurological phenotype to study Huntington’s disease

García Lara, Lucía Gabriela; Morales Martínez, Adriana; Angeles López, Quetzalli Denisse; Pedraza Espitia, Hilda; Pérez Neri, Iván; Rodríguez Balderas, Cesar Augusto; Pérez Severiano, Francisca

Facultad de Medicina Veterinaria y Zootecnia, UNAM, publicado en Veterinaria México OA, y cosechado de Revistas UNAM

Licencia de uso

Procedencia del contenido

Entidad o dependencia
Facultad de Medicina Veterinaria y Zootecnia, UNAM
Revista
Repositorio
Contacto
Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

Cita

García Lara, et al. (2018). Establishment and maintenance of an R6/1 transgenic mouse colony and validation of its progressive neurological phenotype to study Huntington’s disease. Veterinaria México OA; Vol. 5 Núm. 1, 2018. Recuperado de https://repositorio.unam.mx/contenidos/60553

Descripción del recurso

Autor(es)
García Lara, Lucía Gabriela; Morales Martínez, Adriana; Angeles López, Quetzalli Denisse; Pedraza Espitia, Hilda; Pérez Neri, Iván; Rodríguez Balderas, Cesar Augusto; Pérez Severiano, Francisca
Tipo
Artículo de Investigación
Área del conocimiento
Biotecnología y Ciencias Agropecuarias
Título
Establishment and maintenance of an R6/1 transgenic mouse colony and validation of its progressive neurological phenotype to study Huntington’s disease
Fecha
2018-03-14
Resumen
Huntington’s disease (hd) is a hereditary neurodegenerative disorder of the central nervous system that mainly affects the basal ganglia and has no cure. The mutation is located at an abnormal expansion of the cag triplet in the huntingtin gene. humans show psychiatric, behavioural and motor disorders. transgenic animal models are essential to the study of hd since the disease only affects humans. therefore, the aim of this article was to describe the formation and maintenance of and to validate the progressive neurological phenotype of an r6/1 transgenic mouse colony. to achieve our objective, the colony founder was imported from jackson laboratories, and the mice were kept under controlled environmental conditions. The animals were bred at the vivarium of the instituto nacional de neurología y neurocirugía man­uel velasco suárez. The r6/1 transgenic mice were successfully bred and showed genetic and phenotypic characteristics similar to the ones previously reported. our colony is currently established and validated with the condi­tions of our vivarium and has produced more than four generations of r6/1 mice. The establishment of the r6/1 colony and its maintenance through generation is an advantage since it allows us to follow the authenticity of the transgenic mice regarding their phenotypic and motor behaviours. fur­thermore, these animals can be compared with other transgenic mice that reproduce some of the main characteristics of the disease manifested in hu­mans, making these transgenic r6/1 mice a useful tool for the study of hd.figure 2. d) wt mouse with normal fur and weight.
Tema
Huntington’s disease; motor activity; R6/1 transgenic mouse colony; neurodegeneration; motor and behaviour measurements
Idioma
eng
ISSN
ISSN electrónico: 2448-6760

Enlaces