dor_id: 4119787

506.#.#.a: Público

590.#.#.d: Los artículos enviados a la revista "Veterinaria México OA", se juzgan por medio de un proceso de revisión por pares

510.0.#.a: Consejo Nacional de Ciencia y Tecnología (CONACyT); Sistema Regional de Información en Línea para Revistas Científicas de América Latina, el Caribe, España y Portugal (Latindex); Scientific Electronic Library Online (SciELO); Bibliografía Latinoamericana (Biblat); La Red de Revistas Científicas de América Latina y el Caribe, España y Portugal (Redalyc); Connecting research and researchers (ORCiD)

561.#.#.u: https://www.fmvz.unam.mx/

650.#.4.x: Biotecnología y Ciencias Agropecuarias

336.#.#.b: article

336.#.#.3: Artículo de Investigación

336.#.#.a: Artículo

351.#.#.6: https://veterinariamexico.fmvz.unam.mx/index.php/vet/index

351.#.#.b: Veterinaria México OA

351.#.#.a: Artículos

harvesting_group: RevistasUNAM

270.1.#.p: Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx

590.#.#.c: Open Journal Systems (OJS)

270.#.#.d: MX

270.1.#.d: México

590.#.#.b: Concentrador

883.#.#.u: https://revistas.unam.mx/catalogo/

883.#.#.a: Revistas UNAM

590.#.#.a: Coordinación de Difusión Cultural

883.#.#.1: https://www.publicaciones.unam.mx/

883.#.#.q: Dirección General de Publicaciones y Fomento Editorial

850.#.#.a: Universidad Nacional Autónoma de México

856.4.0.u: https://veterinariamexico.fmvz.unam.mx/index.php/vet/article/view/656/598

100.1.#.a: Peña Corona, Sheila; León, Pablo; Mendieta, Enrique; Villanueva, Maximiliano; Salame, Arturo; Vargas, Dinorah; Mora, Guillermo; Serrano, Héctor; Villa Godoy, Alejandro

524.#.#.a: Peña Corona, Sheila, et al. (2019). Effect of a single application of coumestrol and/or dimethyl sulfoxide, on sex hormone levels and vaginal cytology of anestrus bitches. Veterinaria México OA; Vol. 6 Núm. 1, 2019. Recuperado de https://repositorio.unam.mx/contenidos/4119787

245.1.0.a: Effect of a single application of coumestrol and/or dimethyl sulfoxide, on sex hormone levels and vaginal cytology of anestrus bitches

502.#.#.c: Universidad Nacional Autónoma de México

561.1.#.a: Facultad de Medicina Veterinaria y Zootecnia, UNAM

264.#.0.c: 2019

264.#.1.c: 2019-03-22

653.#.#.a: Coumestrol; dimethyl sulfoxide; estradiol; progesterone; vaginal cells; bitches

506.1.#.a: La titularidad de los derechos patrimoniales de esta obra pertenece a las instituciones editoras. Su uso se rige por una licencia Creative Commons BY 4.0 Internacional, https://creativecommons.org/licenses/by/4.0/legalcode.es, para un uso diferente consultar al responsable jurídico del repositorio por medio del correo electrónico vetmexicooa@gmail.com

884.#.#.k: https://veterinariamexico.fmvz.unam.mx/index.php/vet/article/view/656

001.#.#.#: 131.oai:ojs.pkp.sfu.ca:article/656

041.#.7.h: eng

520.3.#.a: Canine overpopulation continues to be a problem with serious public health implications, despite a diversity of programs and strategies that have been implemented for its control. coumestrol (cou) is an organic compound with estrogenic activity, thus having the potential to alter reproduction in mammals. cou is commonly dissolved in dimethyl sulfoxide (dmso) before ad­ministration; however, evidence indicates that dmso is not inert. The aim of this study was to assess the effects of either a single oral administration of cou diluted in dmso or of dmso-alone, on serum progesterone (p4) and estradiol (e2), on vaginal cell pattern, and on anestrus and diestrus lengths in bitches. fifteen anestrus female dogs received either a single commercial dog food biscuit (control, n=5), a biscuit with 600 μg of cou/kg diluted in 20 μl of dmso (cou, n=5), or a biscuit with 20 μl of dmso (dmso, n=5). circulating p4, e2, and changes in vaginal cytology, were assessed within the first month after treatment administration. hormone levels were also measured from months 2-6 post-treatment. mean differences were analyzed by the glm procedure for repeated measures. cou enhanced serum e2 levels, and dmso increased serum p4, number of vaginal anucleated superficial cells, and diestrus length. all dogs were deemed healthy based on all periodical clinical exams, but abnormal mammary gland growth and/or galactorrhea were observed in two cou and one dmso-treated bitches. The findings of the present study expose the need to reevaluate previous reports of use of cou in bitches, and perhaps in other mammals.figure 1. progesterone (a) and estradiol (b) serum levels in anoestrous bitches receiving a commercial dog food biscuit alone (control; n=5), a biscuit with coumestrol diluted in dimethyl sulfoxide (cou; n=5), or a biscuit with only dimethyl sulfoxide (dmso; n=5). a,b different letters within sampling day indicate difference between treatments (p<0.05).*specifies statistical increase on post-treatment days 21 (p<0.0048) and 28 (0.0008). data are presented as lsm ± standard error.

773.1.#.t: Veterinaria México OA; Vol. 6 Núm. 1 (2019)

773.1.#.o: https://veterinariamexico.fmvz.unam.mx/index.php/vet/index

022.#.#.a: ISSN electrónico: 2448-6760

310.#.#.a: Trimestral

264.#.1.b: Facultad de Medicina Veterinaria y Zootecnia, UNAM

doi: https://doi.org/10.22201/fmvz.24486760e.2019.1.656

harvesting_date: 2023-11-08 13:10:00.0

856.#.0.q: application/pdf

file_creation_date: 2019-03-22 21:20:47.0

file_modification_date: 2019-03-22 21:20:56.0

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license_url: https://creativecommons.org/licenses/by/4.0/legalcode.es

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