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División de Estudios de Posgrado, Facultad de Medicina, UNAM
Revista
Repositorio
Contacto
Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx
Autor(es)
Barrios Pérez, Antonio; Cid Oros, Ivette; Becerril Gutiérrez, Carlos; Medina Gómez, Oswaldo S.
Tipo
Artículo de Investigación
Área del conocimiento
Medicina y Ciencias de la Salud
Título
Concordancia entre la prueba de antígenos rápida para SARS-CoV-2 y la prueba diagnóstica de RT-qPCR
Fecha
2024-03-20
Resumen
Objective: to assess the agreement between the rapid antigen testing (RATS) for SARS-CoV-2 and quantitative reverse transcription polymerase chain reaction (RT-qPCR). Methods: analytical cross-sectional study, conducted in three medical units from January 1, 2021, to June 30, 2022, in Mexico City, Mexico. Non-probabilistic sampling was performed using data from the Online Notification System for Epidemiological Surveillance. Data analysis was performed using frequency measures, Cohen’s kappa index, and maximum likelihood estimation. Results: Of 2173 participants with both diagnostic tests: 565 respiratory samples were concordant with a positive result (26.09% CI95% 24.25 - 27.99%), and 1229 with a negative result (56.55% CI95% 54.44 - 58.65%). The sensitivity of RAT versus RT-qPCR was estimated to be 65.17% (95%CI 61.99 - 68.33%), while the specificity was 94.10% (95%CI 92.82 - 95.38%); a positive predictive value of 88.01% (95% CI 85.23 - 90.41%), and a negative predictive value of 80.27% (95%CI 78.19 - 82.24%). The Cohen’s kappa index was 0.62 (substantial agreement), and a calculated likelihood ratio of 40% at pre-test prevalence, a post-test probability of 88.3% was observed for a positive result with RAT in case of having COVID-19. Conclusion: The present study demonstrated substantial concordance between RAT and RT-qPCR, supporting the feasibility of using both tests. This provides clinicians with a valuable tool for informed decision making in the diagnostic context of COVID-19.
Tema
Accuracy; COVID-19; RTqPCR; Antigen; Precisión; COVID-19; RT-qPCR; Antígeno
Idioma
spa
ISSN
ISSN electrónico: 1405-8871
