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Ver términos de la licenciaPeña-Montes, Donovan J., et al. (2024). El papel de la ferroptosis en la enfermedad renal diabética. TIP Revista Especializada en Ciencias Químico-Biológicas; Vol. 27, 2024. Recuperado de https://repositorio.unam.mx/contenidos/4161186
Autor(es)
Peña-Montes, Donovan J.; Saavedra-Molina, Alfredo
Tipo
Artículo de Investigación
Área del conocimiento
Biología y Química
Título
El papel de la ferroptosis en la enfermedad renal diabética
Fecha
2024-12-03
Resumen
Diabetic kidney disease (DKD) is a severe complication of diabetes and the leading cause of end-stage renal disease in Mexico and worldwide. This review examines the complex pathophysiology of DKD, highlighting the emerging role of ferroptosis, an iron-dependent form of regulated cell death. Chronic hyperglycemia, characteristic of diabetes, triggers a cascade of events including oxidative stress, inflammation, and metabolic alterations, creating an environment conducive to ferroptosis in renal tissue. Recent evidence suggests that dysregulation of iron metabolism and exacerbated lipid peroxidation, key elements of ferroptosis, significantly contribute to renal damage in DKD. This review analyzes the interaction between traditional mechanisms of diabetic kidney injury and ferroptosis, exploring how this form of cell death could represent a new therapeutic target. Understanding the role of ferroptosis in DKD is crucial for developing innovative strategies for the prevention and treatment of this complication.
Tema
diabetes; diabetic kidney disease; iron; ferroptosis; cell death; diabetes; enfermedad renal diabética; hierro; ferroptosis; muerte celular
Idioma
spa
ISSN
ISSN electrónico: 2395-8723; ISSN impreso: 1405-888X
