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Centro de Investigaciones Interdisciplinarias en Ciencias y Humanidades, UNAM; Instituto de Ciencias Aplicadas y Tecnología, UNAM; Centro de Nanociencias y Nanotecnología, UNAM
Revista
Repositorio
Contacto
Revistas UNAM. Dirección General de Publicaciones y Fomento Editorial, UNAM en revistas@unam.mx
Morales Noriega, Juan Rafael, et al. (2024). Nanodispersion of TiO2 in hypochlorous acid and its antimicrobial effect against oral pathogens. Mundo Nano. Revista Interdisciplinaria en Nanociencias y Nanotecnología; Vol. 17 Núm. 33, 2024: 2do semestre / Número especial; 1e-17e. Recuperado de https://repositorio.unam.mx/contenidos/4156437
Autor(es)
Morales Noriega, Juan Rafael; López Ayuso, Christian Andrea; Acosta Torres, Laura Susana; Manisekaran, Ravichandran
Tipo
Artículo de Investigación
Área del conocimiento
Multidisciplina
Título
Nanodispersion of TiO2 in hypochlorous acid and its antimicrobial effect against oral pathogens
Fecha
2023-12-14
Resumen
The continuous and inappropriate use of traditionally used antimicrobial agents has caused the rise of multidrug-resistant (MDR) bacterial strains and the mutation of microorganisms in the field of dentistry. Therefore, various nanoparticles have been developed to combat resistant pathogens. Titanium dioxide (TiO2) nanoparticles have been attractive antimicrobial agents because of their chemical stability, non-toxicity, and inexpensive precursors. Therefore, TiO2-based nanodispersions were explored by preparing them with well-known antimicrobial agents, such as hypochlorous acid (HOCl), to enhance the antimicrobial effect. In this study, sol-gel-based TiO2 NPs-HOCl nanodispersions were synthesized and characterized. The antimicrobial effect was assessed by a microdilution assay using S. mutans, S. aureus, ; E. faecalis, and C. albicans strains by incubating different concentrations of the nanodispersions. To evaluate the cytotoxic effects, stem cells from the apical papilla (SCAPs) were inoculated and evaluated using the MTT assay. The nanodispersion exhibited an enhanced antimicrobial effect, with almost no cytotoxicity. The HOCl-based nanodispersion exhibited a greater antimicrobial effect and high stability. Thus, it can be used as a promising antimicrobial agent for the treatment of various dental pathogens.
Idioma
eng
ISSN
ISSN electrónico: 2448-5691; ISSN impreso: 2007-5979
